WebThe introduction of irinotecan has revolutionized the applicability of camptothecins as predominant topoisomerase I inhibitor for anti-cancer therapy. The potent anti-tumor … WebDescription SN-38 (NK012) is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 (NK012) inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively[1][2][3][4]. IC₅₀ & Target Topoisomerase I Camptothecins The IC50 values for LoVo, HCT116, and HT29 cell lines is 20 nM, 50 nM, 130 nM, respectively. In all ...

Epratuzumab–SN-38: A New Antibody–Drug Conjugate for the …

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Web1 day ago · ft ht incxl-7 sn sj_ os et ta td ed el gt g16b j20a rf k9k 700, m13a k9k 266 f10a g13ba g13a h 27 a g16a (8v) h 25 a rhw xud9a, xud9sd rfm rhz suzuki 2720060810 2720060811 2720083000 2720083010, 2720083810 2720083811 2720083812 2720083820 2720060b10 herth+buss, jakoparts j2928000 japanparts jo-805 gmb gus-7 ashika 66-08 … WebSep 9, 2024 · SN-38 abrogates LPS-dependent neutrophil migration and reduced TNF-α, IL-6, and keratinocyte chemoattractant levels in the air-pouch model, but fails to inhibit zymosan (a TLR2 agonist)-induced cell migration. In a word, SN-38 inhibits acute inflammation by blocking LPS-driven TLR4 signaling. In summary, SN-38 is an active … WebSN-38 (NK012) is an active metabolite of CPT-11, inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks. SN-38 induces autophagy. CAS No. 86639-52-3 Selleck's SN-38 has been cited by 53 publications Cell,2024184 (25):6119-6137.e26 Cancer Cell,2024S1535-6108 (21)00659-0 J Exp Clin Cancer Res,202442 (1):8 its 6 o\u0027clock