Webb11 apr. 2024 · Paclitaxel (PTX) is a potent chemotherapeutic widely used to treat breast, lung, pancreatic, and ovarian cancers ().Considered to be one of the most successful cancer drugs of all time, PTX exerts its antitumor effects by stabilizing microtubules and promoting formation of multipolar spindles and chromosome missegregation … WebbIvonne A Müller works at Tumor Biology Center, Breisacher Str. 117, 79106 F and is well known for Prodrug Strategies, Anticancer Chemotherapy and Trigger Groups.
Prodrug Strategies in Anticancer Chemotherapy - Kratz - 2008 ...
Webbproperties (prodrug strategy).20 Since cancers exhibit acquired characteristics that enable their malignant phenotype, there is a need to search for more targetedcancertherapeuticdrugs,whichhasbeensupportedby a better understanding of malignancy at the molecular level. The traits which provide a target for drug therapy … Webb3.Synthesis of Drug Derivatives by Enzymatic Strategy and Preparation of Their ... 9.Experimental Studies on Effect of Thymidine Phosphorylase and Its Modulator Interferon-α in Chemotherapy of Hepatocellular Carcinoma Using Pr-drug ... 1.PurposeTo make efforts to obtain potential anticancer prodrugs for gene-directed enzyme prodrug ... promotional usb credit card wallet
Prodrug Conjugate Strategies in Targeted Anticancer Drug …
Webb11 jan. 2014 · This includes the new prodrugs that have been designed to target a wide variety of anticancer drugs, the prodrugs employed in the course of a combined therapy, the dendritic glucuronide prodrugs and the concept of β-glucuronidase-responsive albumin binding prodrugs. Full text links Webb14 apr. 2024 · Precision cancer medicine strategies. For tumor-specific targeting strategies, four approaches are being investigated, for example, hypoxia-activated prodrugs, hypoxia-selective gene therapy, targeting the hypoxia-inducible factor-1 (HIF-1) transcription factor, and the use of recombinant obligate anaerobic bacteria. Webb1 dec. 2024 · The combinational chemo-immunotherapy as a novel treatment strategy has been widely studied and applied in clinic to enhance antitumor therapeutic efficacy and relieve side effects. promotional umbrellas sydney