Phosphopantetheine binding acp domain

Author: nwve

August undefined, 2024

WebThis multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ( [ACP]) domain. Catalytic activity acetyl-CoA + 2n H+ + n malonyl-CoA + 2n NADPH = a long-chain fatty acid + n CO2 + (n+1) CoA + 2n NADP+ 3 publications WebNov 20, 2024 · Fatty acid and phospholipid metabolism Other PAO1 genes in this class Pathways Functional Predictions from Interpro Search for additional functional domains at the NCBI CDD database website. Go to this protein's …

Probing the Phosphopantetheine Arm Conformations of …

WebChr: 1 Mapping Details/Browsers Description Predicted to enable acyl binding activity and acyl carrier activity. Predicted to act upstream of or within fatty acid biosynthetic process. … http://smart.embl.de/smart/do_annotation.pl?DOMAIN=SM00823 birdsounds europe app

Structural and binding studies of phosphopantetheine …

WebPhosphopantetheine tethering is a posttranslational modification that takes place on the active site serine of carrier proteins138 – ‘acyl carrier proteins (ACPs) and peptidyl carrier proteins (PCPs), also termed thiolation (T) domains’ – during the biosynthesis of fatty acids (FAs) (use ACPs) ( Scheme 23 ), polyketides (PKs) (use ACPs) ( Scheme … WebPhosphopantetheine adenylyltransferase (PPAT, EC. 2.7.7.3) catalyzes an essential step in the reaction that transfers an adenylyl group from adenosine tri phosphate (ATP) to 4' … WebMar 1, 2002 · Furthermore, the helical structure of ACP resembles that of 14-3-3, which suggests that this region of the enzyme may be important in ACP recognition and binding. Therefore, it is likely that the AHL synthase binds acyl-ACP first, followed by a conformational rearrangement of the N-terminal domain and SAM binding in a bi-ter … bird sounds audio robin

Molecular basis for acyl carrier protein–ketoreductase interaction in

MammalianFattyAcidSynthaseinComplexwithNADPH

WebFeb 20, 2024 · Acyl carrier protein (ACP) domains act as interaction hubs within modular polyketide synthase (PKS) systems, employing specific protein-protein interactions to present acyl substrates to a... WebFeb 20, 2024 · Acyl carrier protein (ACP) domains act as interaction hubs within modular polyketide synthase (PKS) systems, employing specific protein-protein interactions to … bird sounds for catWebWelcome to PomBase A comprehensive database for the fission yeast Schizosaccharomyces pombe, providing structural and functional annotation, literature curation and access to large-scale data sets Gene summary Gene standard name lys1 Systematic ID SPAP7G5.04c Product aminoadipate-semialdehyde dehydrogenase … danby 3 in 1 air conditioner manual

"WebJun 2, 2011 · Introduction. One of the most distinctive features of fatty acid, nonribosomal peptide and polyketide biosynthetic pathways is the utilization of the acyl carrier protein (ACP) or peptidyl carrier protein (PCP) for the shuttling of biosynthetic intermediates among various catalytic domains or proteins –.The small and highly dynamic ACPs or PCPs can … " - Phosphopantetheine binding acp domain

Phosphopantetheine binding acp domain

WebOct 5, 2001 · B. subtilis AcpS and its substrate ACP were biochemically characterized. AcpS also modified the d-alanyl carrier protein but failed to recognize PCP and an acyl carrier … WebThis multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. 2 publications Catalytic activity

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WebMar 2, 2010 · Phosphopantetheine binding ACP domain Structure analysis Details Assembly composition: monomeric ( preferred) Entry contents: 1 distinct polypeptide molecule Macromolecule: Norsolorinic acid synthase Molecule details › Chain: A Length: 89 amino acids Theoretical weight: 9.43 KDa Source organism: Aspergillus parasiticus WebSep 5, 2008 · FAS inhibitors have demonstrated anti-tumor activity in vivo and in vitro, and in recent years FAS has emerged as an important drug target for the treatment of human …

WebJul 10, 2024 · Acyl carrier proteins (ACPs) involved in fatty acid and polyketide synthesis, our main interest here, carry an acyl group attached to the ppt arm via a thioester linkage. … WebMar 2, 2010 · 7 malonyl-CoA + hexanoyl- [acyl-carrier protein] = 7 CoA + norsolorinate anthrone + [acyl-carrier protein] + 7 CO (2) + 2 H (2)O. Biochemical function: not assigned. …

Web210-kDa -chain contains a KS domain, a ketoacyl reductase (KR), and a phosphopantetheine transferase domain. In addi-tion, the -chain includes an N-terminal ACP, required for the … Webthe S. cerevisiae FAS (19, 20), the missing ACP domain was subsequently located, docked to the KS domain. We have recently purified the S. cerevisiae fatty acid synthase ... third part binding the CoA or ACP phosphopantetheine group that transfers the acyl and malonyl substrates. In the large fungal fatty acid complex, the KS dimers were ...

WebPhosphopantetheine transferases (PPTases) from E. coli (AcpS) and Bacillus subtilis (Sfp) have been used for the enzyme-mediated protein labeling system ( Fig. 5A ). 143 PPTases catalytically transfer 4′-phosphopantetheine from coenzyme A (CoA) to the serine residue of an acyl carrier protein (ACP) or peptidyl carrier protein (PCP).

WebSep 29, 2024 · A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and … danby 3.8 cu ft chest freezerWebThe phosphopantetheine-attachment site (ACP4: S46 and ACP3a: S62) is highlighted with an asterisk. ... The KR-binding epitope of the ACP domain encompasses key residues situated on H I and H II, and combined with previous observations, 17 the ACP domain docks at the same KR C subdomain site in both cis- and trans-AT systems. bird sounds curlewWebJul 31, 2014 · (1) Movement of the ACP’s phosphopantetheine (Ppant) arm is thought to be coordinated with protein–protein interactions and significant rearrangement of the PKS … danby 3.8 cu ft chest freezer whiteWebFeb 17, 2016 · This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. automatic annotation. Catalytic activity (2E) ... … danby 3.8 cu. ft. chest freezer in whiteWebJul 21, 2024 · The phosphopantetheine-binding domain (PP-binding superfamily), conserved in ACP proteins, is the prosthetic group of ACP, which acts as a linker for the attachment of the activated FA and amino acid groups via a phosphodiester bond (Crawford et al. 2008; Meier et al. 2010; ... bird sounds blue jayWebAn object of the present invention is to provide a microorganism that efficiently produces EPA and a method for producing EPA using the microorganism. The present invention relates to a microorganism having an ability to produce docosahexaenoic acid (DHA), wherein the microorganism contains a protein composed of an amino acid sequence in … bird-sounds.netWebPhosphopantetheine-binding. Status. UniProtKB unreviewed (TrEMBL) ... Family and domain databases. Gene3D. ... IPR036736 ACP-like_sf; IPR020806 PKS_PP-bd; IPR009081 PP … bird sounds free download mp3