WebScreening approaches based on one-bead-one-compound combinatorial libraries have speed up the discovery of novel peptide drugs for cellular targeting in cancer. The OBOC … WebIn this report, one-bead one-compound (OBOC) combinatorial libraries containing the arginine-glycine-aspartic acid (RGD) motif were designed and screened against K562 myeloid leukemia cells that had been transfected with the human αvβ3 integrin gene.
Developments with bead-based screening for novel drug discovery
WebFluorescent quenched substrate libraries are a very powerful tool for investigation of protease activity and specificity. Particularly, libraries where the fluorescent resonance … Web01. jan 2003. · The bead library is then mixed with a target molecule, such as a protein, an enzyme, or other biomolecule, or whole cells and intact microorganisms such as viruses, … go to next line in powershell
The one‐bead two‐compound assay for solid ... - Wiley Online Library
Web28. apr 2009. · Abstract. On-bead screening of one-bead-one-compound (OBOC) libraries provides a powerful method for the rapid identification of active compounds … WebThe one-bead-one-compound (OBOC) library method is in principle ideally suited for this application, because it permits a large number of structurally diverse compounds to be rapidly synthesized and simultaneously screened for binding to a target of interest. WebOne bead–one peptide libraries allow the screening of suitable ligands for any target protein. Short cyclic peptides are ideal ligands for affinity chromatography because of … childern polaroid frames