Web5 apr. 2024 · INTRODUCTION — Treatment for hypercalcemia should be aimed both at lowering the serum calcium concentration and, if possible, treating the underlying disease. Effective treatments reduce serum calcium by inhibiting bone resorption, increasing urinary calcium excretion, or decreasing intestinal calcium absorption ().The optimal choice … Web24 apr. 2024 · BISPHOSPHONATES - Pharmacology Pharmacology Made Simple By Dr. Yogesh Gulati 40.1K subscribers Subscribe 54K views 4 years ago Bisphosphonates, …
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WebFor zoledronic acid. Avoid in tumour-induced hypercalcaemia if serum creatinine above 400 micromol/litre. Avoid in advanced malignancies involving bone if creatinine clearance less than 30 mL/minute (or if serum creatinine greater than 265 micromol/litre). Avoid in Paget’s disease, treatment of postmenopausal osteoporosis and osteoporosis in ... WebThis compound belongs to the class of organic compounds known as bisphosphonates. These are organic compounds containing two phosphonate groups linked together … mongodb download 4.0 version
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WebMechanism of action. Amiloride works by inhibiting sodium reabsorption in the distal convoluted tubules and collecting ducts in the kidneys by binding to the amiloride-sensitive sodium channels. This promotes the loss of sodium and water from the body, but without depleting potassium. WebBisphosphonates Accession Number DBCAT001016 Description Organic compounds which contain P-C-P bonds, where P stands for phosphonates or phosphonic acids. These compounds affect calcium metabolism. They inhibit ectopic calcification and slow down bone resorption and bone turnover. WebBisphosphonates as treatment of bone metastases. Accelerated bone loss is a common clinical feature of advanced breast cancer, and anti-resorptive bisphosphonates are the … mongodb download for windows