Web13 jun. 2005 · Bivalirudin is cleared from plasma by a combination of renal mechanisms (20%) and proteolytic cleavage. Half-life Normal renal function: 25 min (in normal conditions) Creatinine clearance 10-29mL/min: 57min Dialysis-dependant patients: 3.5h Clearance 3.4 mL/min/kg [Normal renal function] 3.4 mL/min/kg [mild renal function] Web9 apr. 2013 · The range of aPTT to titrate bivalirudin was kept between 40 and 60 s. The initiation dose was based on the creatinine clearance (Table 2 ). The loading dose was …
bivalirudin for injection - ADD-VANTAGE Dosage and …
WebPseudo-heparin resistance is fundamentally a monitoring failure. Management involves avoiding the use of PT T to titrate the heparin infusion, for example: (1) If anti-Xa … WebTherapeutic Monitoring. At UWMC, bivalirudin is monitored using the Direct Thrombin Inhibitor (DTI) assay (Plasma-Diluted Thrombin Time). Used instead of aPTT to … ada blitzkrieg depression
Down-titration strategies - NPS MedicineWise
Web20 mrt. 2024 · Usual Adult Dose for Percutaneous Coronary Intervention. For patients who do not have heparin-induced thrombocytopenia (HIT) or heparin-induced … Web27 aug. 2024 · Crossover between the two treatment groups occurred in 0.5% of the patients. The mean maximum activated clotting time during PCI was 386 sec in the bivalirudin group and 305 sec in the heparin ... Web1 jun. 2005 · Bivalirudin is a direct inhibitor of thrombin related to the anticoagulant protein produced by leeches. By reversibly binding to thrombin, bivalirudin stops the conversion of fibrinogen to fibrin and inhibits platelet aggregation. The anticoagulant effect begins within a few minutes of intravenous administration. adabi oriental rugs