Higuchi and connors
WebMar 22, 2024 · We also introduced the Higuchi and Connors method to analyze inclusion complex formed through solubilization and the pharmaceutical benefits that can be gained using CDs. In addition, the practical applications of CDs in nasal, ophthalmic, pulmonary, and rectal drug delivery are also described. CD applications for drug solubilization WebPersonal papers of Takeru Higuchi, PP 359. University of Kansas. Kenneth Spencer Research Library. Higuchi and Connors, "Spectrophotometric Detection of the End Point in the Karl Fischer Titration of Water,", 1959, Box: 11, Folder: 110. Personal papers of Takeru Higuchi, PP 359. University of Kansas. Kenneth Spencer Research Library.
Higuchi and connors
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WebMay 1, 1999 · There are many methods for determination of stability constants of CyD complexes, using techniques such as solubility (Higuchi and Connors, 1965), … WebThe Higuchi窶鼎onnors phase-solubility method8)is very often used to determine K 1:1 , as a part of a formulation study. This method is based on the effect of a complex forming lig- and, e.g.CD, on the solubility of the drug. The intrinsic solu- bility (S 0 ) and the slope of the phase-solubility diagram are then used to calculate K 1:1
WebMar 28, 2014 · Solubility studies were performed according to the method reported by Higuchi and Connors and the phase solubility diagrams were plotted. The repaglinide-nanosponges complexes were prepared, lyophilized and the resulted inclusion complexes were characterized by FT-IR and NMR. WebMay 11, 2024 · Cyclodextrins (CDs), a group of oligosaccharides formed by glucose units bound together in a ring, show a promising ability to form complexes with drug molecules …
WebIt is a blood scihozonticide and active against all stages of Plasmodium falciparum. The drug is also used for the treatment of cerebral malaria as well as for the chloro- quine resistant cases [2-5]. Unfortunately, it is water- insoluble (17 µg/ml at room temperature) [6] and the formulation causes difficulties to the biopharmaceutical scientist. WebThis was explained by the solubilization theory of Higuchi and Connors. The solubility analysis of the ternary drug/competitor/CyD systems may be particularly useful for determination of the stability constant of a drug whose physicochemical and spectroscopic analyses are difficult, because they can be calculated by monitoring the solubility ...
WebDec 18, 2024 · Phase solubility test was performed according to the method of Higuchi and Connors [ 24 ]. An excess amount of camphor was added to aqueous CD (HPβCD and HPγCD) solutions, and the suspensions were shaken at RT. After equilibrium was achieved at the end of 48 h, the suspensions were filtered with 0.45 μm membrane filter.
WebTypes of phase-solubility diagrams according to Higuchi and Connors [11] showing how the total drug solubility changes with increasing CD concentration. A-type diagrams are … east of eden novel wikipediaWebMar 30, 2024 · The phase solubility study was carried out according to the method of Higuchi and Connors ( Higuchi, & Connors, 1965 ). Specifically, excessive APG (approximately 10 mg) was added to 5 mL of ethanol–water (30:70, v/v) solution containing different concentrations of OMT in the range of 5–300 mM. culver city johnnie\\u0027s pastramiWebJan 30, 2024 · According to Higuchi and Connors (1965), the linear host-guest correlation can be classified as linear diagram (A L) type because the straight line had a slope of less than 1 in each compound, i.e., 0.0074, 0.0202 and 0.0266 for curcumin, demethoxycurcumin, and bisdemethoxycurcumin, respectively. The result indicated that one mole of ... east of eden phimWebApr 7, 2024 · The most dramatic increase in solubility of curcumin was obtained more than 20 times higher by solidly dispersed complex of CUR with PEG 6000 (1:3) than its intrinsic solubility. Following the classification of Higuchi and Connors, CUR in different PEG 6000 solutions showed A N diagram. east of eden plotWebThe most common and widely used method to evaluate the ability of the inclusion complex is the phase solubility studies by Higuchi and Connors (1965). 23 The plot showed that … culver city johnnie\u0027s pastramiWebT K Higuchi, A Connors 31 Dec 1964 - Vol. 4, pp 212-217 About: The article was published on 1965-01-01 and is currently open access. It has received 2363 citation (s) till now. The … culver city julian dixon libraryWebIn a famous publication by Higuchi and Connors, complexes were classified based on the phase solubility profiles derived from the molecular interactions between the host and the … east of eden quotes explained